BDBM688776 US20240190889, Example 21::[(7S,13R)-13-(difluoromethyl)-9-(2,6-difluorophenyl)-7-methyl-16-thia-2,5,8-triazatetracyclo [8.6.0.02,6.011,15]hexadeca-1(10),3,5,8,11(15)-pentaen-3-yl]methanol

SMILES C[C@@H]1N=C(c2c3C[C@H](Cc3sc2-n2c(CO)cnc12)C(F)F)c1c(F)cccc1F

InChI Key InChIKey=FCKVAABCJRWYHI-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 688776   

LigandPNGBDBM688776(US20240190889, Example 21 | [(7S,13R)-13-(difluoro...)
Affinity DataKi:  2.97nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688776(US20240190889, Example 21 | [(7S,13R)-13-(difluoro...)
Affinity DataKi:  4.70nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688776(US20240190889, Example 21 | [(7S,13R)-13-(difluoro...)
Affinity DataKi:  606nMAssay Description:The affinity of compounds at GABAA γ2 subunit-containing receptors was measured by competition for [3H]Flumazenil (81.1 Ci/mmol; Roche) binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent