BDBM688778 (R)-3-(2-ethynyl-5-fluoropyrimidin-4-yl)-10-methyl-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one::US20240190890, Compound I-1

SMILES C[C@@H]1CNc2c(sc3ccc4nc(ccc4c23)-c2nc(ncc2F)C#C)C(=O)N1

InChI Key InChIKey=BVVCWHNWISHTIJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 688778   

LigandPNGBDBM688778(US20240190890, Compound I-1 | (R)-3-(2-ethynyl-5-f...)
Affinity DataIC50: 5nMAssay Description:Inhibition of MK2 (unknown origin) using ST3-Sox peptide as substrate measured for 120 mins in presence of ATP by Synergy H4 plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM688778(US20240190890, Compound I-1 | (R)-3-(2-ethynyl-5-f...)
Affinity DataIC50: 5nMAssay Description:Briefly, 10× stock solutions of MK2 (PV3317, from Life Technologies), 1.13X ATP (AS001A), and Sox conjugated peptide substrate, S/T3-Sox, (KZN1031) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent