BDBM688896 (R)-10-methyl-3-(2-(3-(pyrrolidin-1-yl)prop-1-en-2-yl)pyridin-4-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one::US20240190890, Compound I-116

SMILES C[C@@H]1CNc2c(sc3ccc4nc(ccc4c23)-c2ccnc(c2)C(=C)CN2CCCC2)C(=O)N1

InChI Key InChIKey=RWRSVHUIDMAEHB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 688896   

TargetMAP kinase-activated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM688896(US20240190890, Compound I-116 | (R)-10-methyl-3-(2...)
Affinity DataIC50: 6nMAssay Description:Briefly, 10× stock solutions of MK2 (PV3317, from Life Technologies), 1.13X ATP (AS001A), and Sox conjugated peptide substrate, S/T3-Sox, (KZN1031) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetMAP kinase-activated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM688896(US20240190890, Compound I-116 | (R)-10-methyl-3-(2...)
Affinity DataIC50: 6nMAssay Description:Inhibition of MK2 (unknown origin) using ST3-Sox peptide as substrate measured for 120 mins in presence of ATP by Synergy H4 plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed