BDBM689549 US12054497, Compound Z1::US12054497, Compound Z1-1::US12054497, Compound Z1-2

SMILES CC(C)c1nccc(C)c1-n1c2nc(c(F)cc2c2N3CCN(C[C@@H]3COc2c1=O)C(=O)C=C)-c1c(O)cccc1F

InChI Key InChIKey=IDELLCCPXMATNN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 689549   

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689549(US12054497, Compound Z1-1 | US12054497, Compound Z...)
Affinity DataIC50: 152nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689549(US12054497, Compound Z1-1 | US12054497, Compound Z...)
Affinity DataIC50: 255nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689549(US12054497, Compound Z1-1 | US12054497, Compound Z...)
Affinity DataIC50: 1.43E+3nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
US Patent