BDBM689554 US12054497, Compound Z10::US12054497, Compound Z10-1::US12054497, Compound Z10-2

SMILES CC(C)c1nccc(C)c1-n1c2nc(c(F)cc2c2N3C[C@@H](C)N(C[C@@H]3C(=O)N(C)c2c1=O)C(=O)C=C)-c1c(O)cccc1F

InChI Key InChIKey=XKOILGZECZCVHC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 689554   

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689554(US12054497, Compound Z10-2 | US12054497, Compound ...)
Affinity DataIC50: 37nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689554(US12054497, Compound Z10-2 | US12054497, Compound ...)
Affinity DataIC50: 67nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689554(US12054497, Compound Z10-2 | US12054497, Compound ...)
Affinity DataIC50: 708nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
US Patent