BDBM689572 US12054497, Compound Z30

SMILES CCN1C(=O)[C@H]2CN(CCN2c2c1c(=O)n(-c1c(C)ccnc1C(C)C)c1nc(c(F)cc21)-c1c(O)cccc1F)C(=O)C=C

InChI Key InChIKey=MLHDLLCVPRYCHJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 689572   

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689572(US12054497, Compound Z30)
Affinity DataIC50: 656nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
US Patent