BDBM689576 US12054497, Compound Z35

SMILES CC(C)c1nccc(C)c1-n1c2nc(c(F)cc2c2N3C[C@@H](C)N(C[C@@H]3C(=O)Nc2c1=O)C(=O)C=C)-c1c(O)cccc1F

InChI Key InChIKey=NOCNNWKULVKEBP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 689576   

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689576(US12054497, Compound Z35)
Affinity DataIC50: 73nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
US Patent