BDBM690500 US12065430, Example 18

SMILES C=CC(=O)N1CC(NC(=O)c2c(C)nc(CNc3n[nH]c4cc(Cl)c(C(C)(C)C)cc34)n2CCCC)C1

InChI Key InChIKey=QYVKEPLIQPUGSS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 690500   

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 690500BDBM690500(US12065430, Example 18)
Affinity DataIC50: 12nMAssay Description:The inhibitory activity of compounds on exchange reaction of GDP into GppNHp in Bodipy (trademark) FL-bound KRAS G12C was examined by fluorescence me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent