BDBM690501 US12065430, Example 19

SMILES C=CC(=O)N1CC(NC(=O)c2c(C)nc(CNc3n[nH]c4cc(Cl)c(C(C)(C)C)cc34)n2CCC)C1

InChI Key InChIKey=YLCDYDBIDJTWMS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 690501   

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 690501BDBM690501(US12065430, Example 19)
Affinity DataIC50: 9nMAssay Description:The inhibitory activity of compounds on exchange reaction of GDP into GppNHp in Bodipy (trademark) FL-bound KRAS G12C was examined by fluorescence me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent