BDBM691375 US12065447, Compound ZB-R-82

SMILES CN1c2sc(C#Cc3cncn3C)c(C)c2SC[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O

InChI Key InChIKey=JSTHVFPCMOKANM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 691375   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM691375(US12065447, Compound ZB-R-82)
Affinity DataIC50: 0.300nMAssay Description:TNFalpha induced U937 cell programmed necroptosis system was used to screen for compounds with RIP 1 kinase inhibitory activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent