BDBM691376 US12065447, Compound ZB-R-84

SMILES COCC#Cc1sc2N(C)C(=O)[C@H](CSc2c1C)NC(=O)c1nnc(Cc2ccccc2)[nH]1

InChI Key InChIKey=JZNYUHYHPNUBNQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 691376   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM691376(US12065447, Compound ZB-R-84)
Affinity DataIC50: 0.190nMAssay Description:TNFalpha induced U937 cell programmed necroptosis system was used to screen for compounds with RIP 1 kinase inhibitory activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent