BDBM692043 4-(((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)amino)-6-((3R,4R)-3-fluorotetrahydro-2H-pyran-4-yl)-2-methyl-2,6-dihydropyrido[3,4-d]pyridazine-1,7-dione (example 32, tetrahydropyran absolute stereochemistry arbitrarily assigned) and 4-(((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)amino)-6-((3S,4S)-3-fluorotetrahydro-2H-pyran-4-yl)-2-methyl-2,6-dihydropyrido[3,4-d]pyridazine-1,7-dione (example 33, tetrahydropyran absolute stereochemistry arbitrarily assigned)::US20240279221, Example 32::US20240279221, Example 33
SMILES C[C@@H](Nc1nn(C)c(=O)c2cc(=O)n(cc12)[C@H]1CCOC[C@H]1F)c1cccc(C(F)F)c1F
InChI Key InChIKey=DHCASOHRGBPFRB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 692043
Affinity DataKd: 8nMAssay Description:Binding to SOS1 was measured using a SPR assay with purified recombinant human SOS1 substrate (res. 564-1049 with N-terminal Avi tag; purified and bi...More data for this Ligand-Target Pair
Affinity DataIC50: 31.3nMAssay Description:Inhibition of the SOS1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl Ac...More data for this Ligand-Target Pair
Affinity DataKd: 229nMAssay Description:Binding to SOS1 was measured using a SPR assay with purified recombinant human SOS1 substrate (res. 564-1049 with N-terminal Avi tag; purified and bi...More data for this Ligand-Target Pair
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of the SOS1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl Ac...More data for this Ligand-Target Pair