BDBM692045 6-cyclopropyl-2-methyl-4-(((R)-1-(2-methyl-3-(trifluoromethyl)phenyl)ethyl)amino)-8-((S)-pyrrolidin-2-yl)-2,6-dihydropyrido[3,4-d]pyridazine-1,7-dione (example 34, Absolute stereochemistry at pyrrolidine arbitrarily defined) and 6-cyclopropyl-2-methyl-4-(((R)-1-(2-methyl-3-(trifluoromethyl)phenyl)ethyl)amino)-8-((R)-pyrrolidin-2-yl)-2,6-dihydropyrido[3,4-d]pyridazine-1,7-dione (example 35, Absolute stereochemistry at pyrrolidine arbitrarily defined)::US20240279221, Example 34::US20240279221, Example 35
SMILES C[C@@H](Nc1nn(C)c(=O)c2c([C@H]3CCCN3)c(=O)n(cc12)C1CC1)c1cccc(c1C)C(F)(F)F
InChI Key InChIKey=MFHBJGXWJWBFAM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 692045
Affinity DataKd: 10nMAssay Description:Binding to SOS1 was measured using a SPR assay with purified recombinant human SOS1 substrate (res. 564-1049 with N-terminal Avi tag; purified and bi...More data for this Ligand-Target Pair
Affinity DataKd: 17nMAssay Description:Binding to SOS1 was measured using a SPR assay with purified recombinant human SOS1 substrate (res. 564-1049 with N-terminal Avi tag; purified and bi...More data for this Ligand-Target Pair
Affinity DataIC50: 43.9nMAssay Description:Inhibition of the SOS1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl Ac...More data for this Ligand-Target Pair
Affinity DataIC50: 78.4nMAssay Description:Inhibition of the SOS1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl Ac...More data for this Ligand-Target Pair