BDBM692066 2-methyl-4-(((R)-1-(2-methyl-3-(trifluoromethyl)phenyl)ethyl)amino)-6-((S)-3-methyltetrahydrofuran-3-yl)-2,6-dihydropyrido[3,4-d]pyridazine-1,7-dione (example 54, stereochemistry at tetrahydrofuran ring is arbitrarily assigned) and 2-methyl-4-(((R)-1-(2-methyl-3-(trifluoromethyl)phenyl)ethyl)amino)-6-((R)-3-methyltetrahydrofuran-3-yl)-2,6-dihydropyrido[3,4-d]pyridazine-1,7-dione (example 55, stereochemistry at tetrahydrofuran ring is arbitrarily assigned)::US20240279221, Example 54::US20240279221, Example 55
SMILES C[C@@H](Nc1nn(C)c(=O)c2cc(=O)n(cc12)[C@]1(C)CCOC1)c1cccc(c1F)C(F)(F)F
InChI Key InChIKey=JLSDNOUPLMCTRP-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 692066
Affinity DataKd: 14nMAssay Description:Binding to SOS1 was measured using a SPR assay with purified recombinant human SOS1 substrate (res. 564-1049 with N-terminal Avi tag; purified and bi...More data for this Ligand-Target Pair
Affinity DataIC50: 32.2nMAssay Description:Inhibition of the SOS1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl Ac...More data for this Ligand-Target Pair
Affinity DataKd: 125nMAssay Description:Binding to SOS1 was measured using a SPR assay with purified recombinant human SOS1 substrate (res. 564-1049 with N-terminal Avi tag; purified and bi...More data for this Ligand-Target Pair
Affinity DataIC50: 285nMAssay Description:Inhibition of the SOS1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl Ac...More data for this Ligand-Target Pair