BDBM692111 6-((S)-1-acetyl-3-(trifluoromethyl)pyrrolidin-3-yl)-4-(((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)amino)-2-methyl-2,6-dihydropyrido[3,4-d]pyridazine-1,7-dione (example 99, absolute stereochemistry at pyrrolidine is arbitrarily assigned) and 6-((R)-1-acetyl-3-(trifluoromethyl)pyrrolidin-3-yl)-4-(((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)amino)-2-methyl-2,6-dihydropyrido[3,4-d]pyridazine-1,7-dione (example 100, absolute stereochemistry at pyrrolidine is arbitrarily assigned)::US20240279221, Example 100::US20240279221, Example 99
SMILES C[C@@H](Nc1nn(C)c(=O)c2cc(=O)n(cc12)[C@]1(CCN(C1)C(C)=O)C(F)(F)F)c1cccc(C(F)F)c1F
InChI Key InChIKey=NVEVZVXXNJOHMK-UHFFFAOYSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 692111
Affinity DataIC50: 9.03nMAssay Description:Inhibition of the SOS1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl Ac...More data for this Ligand-Target Pair
Affinity DataIC50: 1.92E+3nMAssay Description:Inhibition of the SOS1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl Ac...More data for this Ligand-Target Pair