BDBM692133 US20240279221, Example 120

SMILES C[C@@H](Nc1nn(C)c(=O)c2cc(=O)n(cc12)[C@]1(CCOC1)C(F)F)c1cccc(C(F)F)c1F

InChI Key InChIKey=QMDGKCOXYULFCO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 692133   

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
SchröDinger

US Patent
LigandPNGBDBM692133(US20240279221, Example 120)
Affinity DataIC50: 19.9nMAssay Description:Inhibition of the SOS1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl Ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent