BDBM692168 US20240279221, Example 154

SMILES C[C@@H](Nc1nn(C)c(=O)c2cc(=O)n(cc12)C1(CN(C1)C(C)=O)C(F)F)c1cccc(C(F)F)c1F

InChI Key InChIKey=JLQAPPCOFLZNQJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 692168   

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
SchröDinger

US Patent
LigandPNGBDBM692168(US20240279221, Example 154)
Affinity DataIC50: 18.5nMAssay Description:Inhibition of the SOS1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl Ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent