BDBM692175 4-[[(1R)-1-[3-(1,1-difluoro-2-methoxy-ethyl)-2-fluoro-phenyl]ethyl]amino]-6-[1-(difluoromethyl)cyclopropyl]-2-methyl-pyrido[3,4-d]pyridazine-1,7-dione::US20240279221, Example 161::US20240279221, Example 162

SMILES COCC(F)(F)c1cccc([C@H](C)Nc2nn(C)c(=O)c3cc(=O)n(cc23)C2(CC2)C(F)F)c1F

InChI Key InChIKey=JFNJHTXHXOJEEF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 692175   

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
SchröDinger

US Patent
LigandPNGBDBM692175(US20240279221, Example 162 | 4-[[(1R)-1-[3-(1,1-di...)
Affinity DataIC50: 24.9nMAssay Description:Inhibition of the SOS1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl Ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
SchröDinger

US Patent
LigandPNGBDBM692175(US20240279221, Example 162 | 4-[[(1R)-1-[3-(1,1-di...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of the SOS1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl Ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent