BDBM692178 4-(((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)amino)-2-methyl-6-((S)-3-(trifluoromethyl)tetrahydrofuran-3-yl)-2,6-dihydropyrido[3,4-d]pyridazine-1,7-dione::US20240279221, Example 164::US20240279221, Example 165

SMILES C[C@@H](Nc1nn(C)c(=O)c2cc(=O)n(cc12)[C@]1(CCOC1)C(F)(F)F)c1cccc(C(F)F)c1F

InChI Key InChIKey=SRWVKWSMPUKKNA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 692178   

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
SchröDinger

US Patent
LigandPNGBDBM692178(US20240279221, Example 164 | 4-(((R)-1-(3-(difluor...)
Affinity DataIC50: 19.3nMAssay Description:Inhibition of the SOS1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl Ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
SchröDinger

US Patent
LigandPNGBDBM692178(US20240279221, Example 164 | 4-(((R)-1-(3-(difluor...)
Affinity DataIC50: 424nMAssay Description:Inhibition of the SOS1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl Ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent