BDBM692186 6-((S)-1-acetyl-3-(trifluoromethyl)pyrrolidin-3-yl)-4-(((R)-1-(3-fluorobenzofuran-7-yl)ethyl)amino)-2-methyl-2,6-dihydropyrido[3,4-d]pyridazine-1,7-dione::US20240279221, Example 172::US20240279221, Example 173

SMILES C[C@@H](Nc1nn(C)c(=O)c2cc(=O)n(cc12)[C@@]1(CCN(C1)C(C)=O)C(F)(F)F)c1cccc2c(F)coc12

InChI Key InChIKey=GFUSHJSERPEHSH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 692186   

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
SchröDinger

US Patent
LigandPNGBDBM692186(US20240279221, Example 172 | 6-((S)-1-acetyl-3-(tr...)
Affinity DataIC50: 13.8nMAssay Description:Inhibition of the SOS1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl Ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
SchröDinger

US Patent
LigandPNGBDBM692186(US20240279221, Example 172 | 6-((S)-1-acetyl-3-(tr...)
Affinity DataIC50: 2.79E+3nMAssay Description:Inhibition of the SOS1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl Ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent