BDBM692191 (R)-4-((1-(3-(difluoro(5-methylpyrazin-2-yl)methyl)-2-fluorophenyl)ethyl)amino)-6-(1-(difluoromethyl)cyclopropyl)-2-methyl-2,6-dihydropyrido[3,4-d]pyridazine-1,7-dione and (S)-4-((1-(3-(difluoro(5-methylpyrazin-2-yl)methyl)-2-fluorophenyl)ethyl)amino)-6-(1-(difluoromethyl)cyclopropyl)-2-methyl-2,6-dihydropyrido[3,4-d]pyridazine-1,7-dione::US20240279221, Example 176::US20240279221, Example 177

SMILES C[C@H](Nc1nn(C)c(=O)c2cc(=O)n(cc12)C1(CC1)C(F)F)c1cccc(c1F)C(F)(F)c1cnc(C)cn1

InChI Key InChIKey=SCXLKCKRVYRCOP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 692191   

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
SchröDinger

US Patent
LigandPNGBDBM692191(US20240279221, Example 177 | (R)-4-((1-(3-(difluor...)
Affinity DataIC50: 20.1nMAssay Description:Inhibition of the SOS1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl Ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
SchröDinger

US Patent
LigandPNGBDBM692191(US20240279221, Example 177 | (R)-4-((1-(3-(difluor...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of the SOS1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl Ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent