BDBM692595 (7S)-11-chloro-9-(2,6-difluorophenyl)-N-[(2R)-2-hydroxypropyl]-7-methyl-12-(trifluoromethyl)-2,3,5,8,13-pentazatricyclo[8.4.0.02,6]tetradeca-1::US20240270744, Example 16

SMILES C[C@@H](O)CNC(=O)c1nc2[C@H](C)N=C(c3c(F)cccc3F)c3c(Cl)c(ncc3-n2n1)C(F)(F)F

InChI Key InChIKey=RXBGGFMEZUKQME-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 692595   

LigandPNGBDBM692595(US20240270744, Example 16 | (7S)-11-chloro-9-(2,6-...)
Affinity DataKi:  4.10nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
US Patent

LigandPNGBDBM692595(US20240270744, Example 16 | (7S)-11-chloro-9-(2,6-...)
Affinity DataKi:  39.8nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
US Patent

LigandPNGBDBM692595(US20240270744, Example 16 | (7S)-11-chloro-9-(2,6-...)
Affinity DataKi:  157nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
US Patent

LigandPNGBDBM692595(US20240270744, Example 16 | (7S)-11-chloro-9-(2,6-...)
Affinity DataKi:  9.47E+3nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
US Patent