BDBM692632 7-((2S,5R)-2,5-diethyl-4-(1-(quinoxalin-6-yl)ethyl)piperazin-1-yl)-4-methyl-2-(prop-1-en-2-yl)-2,4-dihydro-5H-pyrazolo[4,3-b]pyridin-5-one::US20240270751, Compound A25::US20240270751, Compound A26

SMILES CC[C@@H]1CN([C@@H](CC)CN1C(C)c1ccc2nccnc2c1)c1cc(=O)n(C)c2cn(nc12)C(C)=C

InChI Key InChIKey=NXGWWAPBLQBXRZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 692632   

TargetDiacylglycerol kinase alpha(Human)
Beigene

US Patent
LigandPNGBDBM692632(US20240270751, Compound A25 | 7-((2S,5R)-2,5-dieth...)
Affinity DataIC50: 4.30nMAssay Description:The inhibition activities testing for the compound disclosed herein were carried out at room temperature in assay buffer containing 50 mM HEPES, 10 m...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
US Patent

TargetDiacylglycerol kinase alpha(Human)
Beigene

US Patent
LigandPNGBDBM692632(US20240270751, Compound A25 | 7-((2S,5R)-2,5-dieth...)
Affinity DataIC50: 54nMAssay Description:The inhibition activities testing for the compound disclosed herein were carried out at room temperature in assay buffer containing 50 mM HEPES, 10 m...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
US Patent

TargetDiacylglycerol kinase zeta(Human)
Beigene

US Patent
LigandPNGBDBM692632(US20240270751, Compound A25 | 7-((2S,5R)-2,5-dieth...)
Affinity DataIC50: 510nMAssay Description:The inhibition activities testing for the compound disclosed herein were carried out at room temperature in assay buffer containing 50 mM HEPES, 10 m...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
US Patent

TargetDiacylglycerol kinase zeta(Human)
Beigene

US Patent
LigandPNGBDBM692632(US20240270751, Compound A25 | 7-((2S,5R)-2,5-dieth...)
Affinity DataIC50: 9.80E+4nMAssay Description:The inhibition activities testing for the compound disclosed herein were carried out at room temperature in assay buffer containing 50 mM HEPES, 10 m...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
US Patent