BDBM692695 2-(7-((2S,5R)-2,5-diethyl-4-(1-(5- fluoropyridin-2-yl)ethyl)piperazin- 1-yl)-4-methyl-5-oxo-4,5-dihydro- 2H-pyrazolo[4,3-b]pyridin-2- yl)acetonitrile::US20240270751, Compound A74

SMILES CC[C@@H]1CN([C@@H](CC)CN1C(C)c1ccc(F)cn1)c1cc(=O)n(C)c2cn(CC#N)nc12

InChI Key InChIKey=VTSHKKONDMPIMA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 692695   

TargetDiacylglycerol kinase alpha(Human)
Beigene

US Patent
LigandPNGBDBM692695(2-(7-((2S,5R)-2,5-diethyl-4-(1-(5- fluoropyridin-2...)
Affinity DataIC50: 3.80nMAssay Description:The inhibition activities testing for the compound disclosed herein were carried out at room temperature in assay buffer containing 50 mM HEPES, 10 m...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
US Patent

TargetDiacylglycerol kinase zeta(Human)
Beigene

US Patent
LigandPNGBDBM692695(2-(7-((2S,5R)-2,5-diethyl-4-(1-(5- fluoropyridin-2...)
Affinity DataIC50: 830nMAssay Description:The inhibition activities testing for the compound disclosed herein were carried out at room temperature in assay buffer containing 50 mM HEPES, 10 m...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
US Patent