BDBM693131 4-((1R,5S)-3,8-diazabicyclo[3.2.1]oct-6-en-3-yl)-7-(8-ethynylnaphthalen-1-yl)-8-fluoro-2-((tetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)pyrido[4,3-d]pyrimidine::US20240270758, Example Z6

SMILES Fc1c(ncc2c(nc(OCC34CCCN3CCC4)nc12)N1C[C@H]2N[C@@H](C1)C=C2)-c1cccc2cccc(C#C)c12

InChI Key InChIKey=VFTPSIFWRGZALH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 693131   

TargetGTPase KRas [G12D]/RAF proto-oncogene serine/threonine-protein kinase(Human)
Genfleet Therapeutics (Shanghai)

US Patent
LigandPNGBDBM693131(4-((1R,5S)-3,8-diazabicyclo[3.2.1]oct-6-en-3-yl)-7...)
Affinity DataIC50: 51.6nMAssay Description:This experiment is intended to investigate the inhibitory effect of compounds on the binding of KRASG12D mutant protein or KRASWt (wild type) protein...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
Go to US Patent

TargetGTPase KRas/RAF proto-oncogene serine/threonine-protein kinase(Human)
Genfleet Therapeutics (Shanghai)

US Patent
LigandPNGBDBM693131(4-((1R,5S)-3,8-diazabicyclo[3.2.1]oct-6-en-3-yl)-7...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
Go to US Patent