BDBM693134 5-ethynyl-4-(8-fluoro-2-((tetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-((1R,2S,4R, 5S)-7,9-diazatricyclo[3.3.1.02′4]nonan-7-yl)pyrido[4,3-d]pyrimidin-7-yl)naphthalen-2-ol::US20240270758, Example Z10

SMILES Oc1cc(-c2ncc3c(nc(OCC45CCCN4CCC5)nc3c2F)N2CC3NC(C2)C2CC32)c2c(cccc2c1)C#C

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 693134   

TargetGTPase KRas [G12D]/RAF proto-oncogene serine/threonine-protein kinase(Human)
Genfleet Therapeutics (Shanghai)

US Patent
LigandPNGBDBM693134(5-ethynyl-4-(8-fluoro-2-((tetrahydro-1H-pyrrolizin...)
Affinity DataIC50: 62.9nMAssay Description:This experiment is intended to investigate the inhibitory effect of compounds on the binding of KRASG12D mutant protein or KRASWt (wild type) protein...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
US Patent

TargetGTPase KRas/RAF proto-oncogene serine/threonine-protein kinase(Human)
Genfleet Therapeutics (Shanghai)

US Patent
LigandPNGBDBM693134(5-ethynyl-4-(8-fluoro-2-((tetrahydro-1H-pyrrolizin...)
Affinity DataIC50: 119nMMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
US Patent