BDBM693143 4-(4-(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-6,8-difluoro-2-(2-methylenetetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)quinazolin-7-yl)-5-ethynylnaphthalen-2-ol::US20240270758, Example Z20

SMILES C#Cc1cccc2cc(O)cc(-c3c(F)cc4c(N5CC6CCC(C5)N6)nc(OCC56CCCN5CC(=C)C6)nc4c3F)c12

InChI Key InChIKey=ATJAYCWNRYSMBL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 693143   

TargetGTPase KRas [G12D]/RAF proto-oncogene serine/threonine-protein kinase(Human)
Genfleet Therapeutics (Shanghai)

US Patent
LigandChemical structure of BindingDB Monomer ID 693143BDBM693143(4-(4-(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-6,...)
Affinity DataIC50: 105nMAssay Description:This experiment is intended to investigate the inhibitory effect of compounds on the binding of KRASG12D mutant protein or KRASWt (wild type) protein...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
US Patent

TargetGTPase KRas/RAF proto-oncogene serine/threonine-protein kinase(Human)
Genfleet Therapeutics (Shanghai)

US Patent
LigandChemical structure of BindingDB Monomer ID 693143BDBM693143(4-(4-(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-6,...)
Affinity DataIC50: 110nMMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
US Patent