BDBM693248 (S)-N-(2-fluoro-5-methyl-4-(3-(2- (piperidin-3-ylamino)pyrimidin-4- yl)pyridin-2- yloxy)phenyl)(phenyl)methanesulfonamide::US12071425, Compound 158

SMILES Cc1cc(NS(=O)(=O)Cc2ccccc2)c(F)cc1Oc1ncccc1-c1ccnc(N[C@H]2CCCNC2)n1

InChI Key InChIKey=IFKMTMVDPOQDQT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 693248   

LigandPNGBDBM693248((S)-N-(2-fluoro-5-methyl-4-(3-(2- (piperidin-3-yla...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of His-tagged IRE1alpha (G547 to L977 residues) (unknown origin) expressed in Sf9 cells preincubated with anti-His Europium labeled antibo...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM693248((S)-N-(2-fluoro-5-methyl-4-(3-(2- (piperidin-3-yla...)
Affinity DataIC50: 5.10nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693248((S)-N-(2-fluoro-5-methyl-4-(3-(2- (piperidin-3-yla...)
Affinity DataIC50: 14nMAssay Description:Inhibition of IRE1alpha RNase activity (Q470 to L977 residues) (unknown origin) expressed in Sf9 cells using mini-XBP-1 stem-loop RNA as substrate me...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM693248((S)-N-(2-fluoro-5-methyl-4-(3-(2- (piperidin-3-yla...)
Affinity DataIC50: 310nMAssay Description:Inhibition of IRE1alpha RNase activity (unknown origin) using XBP1 as substrate preincubated for 1 hr followed by thapsigargin stimulation for 5 hrs ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed