BDBM693250 (S)-N-(2,3-difluoro-6-methyl-4-((3-(2- (piperiidn-3-ylamino)pyrimidin-4- yl)pyridin-2-yl)oxy)phenyl)-1- phenylmethanesulfonamide::US12071425, Compound 160
SMILES Cc1cc(Oc2ncccc2-c2ccnc(N[C@H]3CCCNC3)n2)c(F)c(F)c1NS(=O)(=O)Cc1ccccc1
InChI Key InChIKey=QPRFTBDGRCHUGW-UHFFFAOYSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 693250
Affinity DataIC50: 0.290nMAssay Description:Inhibition of His-tagged IRE1alpha (G547 to L977 residues) (unknown origin) expressed in Sf9 cells preincubated with anti-His Europium labeled antibo...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 4.5nMAssay Description:Inhibition of IRE1alpha RNase activity (Q470 to L977 residues) (unknown origin) expressed in Sf9 cells using mini-XBP-1 stem-loop RNA as substrate me...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 5.40nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 44nMAssay Description:Inhibition of IRE1alpha RNase activity (unknown origin) using XBP1 as substrate preincubated for 1 hr followed by thapsigargin stimulation for 5 hrs ...More data for this Ligand-Target Pair
Ligand InfoSimilars