BDBM693327 N-[2-fluoro-3-methyl-4-[[3-[2-[[(3S)-3- piperidyl]amino]pyrimidin-4-yl]-2- pyridyl]oxy]phenyl]-1 phenylmethanesulfonamide::US12071425, Compound 237
SMILES Cc1c(F)c(NS(=O)(=O)Cc2ccccc2)ccc1Oc1ncccc1-c1ccnc(N[C@H]2CCCNC2)n1
InChI Key InChIKey=GYCMERFIKQCCQP-UHFFFAOYSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 693327
Affinity DataIC50: 1.80nMAssay Description:Inhibition of His-tagged IRE1alpha (G547 to L977 residues) (unknown origin) expressed in Sf9 cells preincubated with anti-His Europium labeled antibo...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 8.40nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 24nMAssay Description:Inhibition of IRE1alpha RNase activity (Q470 to L977 residues) (unknown origin) expressed in Sf9 cells using mini-XBP-1 stem-loop RNA as substrate me...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 330nMAssay Description:Inhibition of IRE1alpha RNase activity (unknown origin) using XBP1 as substrate preincubated for 1 hr followed by thapsigargin stimulation for 5 hrs ...More data for this Ligand-Target Pair
Ligand InfoSimilars