BDBM694185 8,9-dichloro-7-(2-fluorophenyl)-5H-pyrimido[1,2-a][1,4]benzodiazepin-3-one::US20240287082, Example 1

SMILES Fc1ccccc1C1=NCc2nc(=O)ccn2-c2ccc(Cl)c(Cl)c12

InChI Key InChIKey=VPHVDBRFNLXIHE-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 694185   

LigandPNGBDBM694185(8,9-dichloro-7-(2-fluorophenyl)-5H-pyrimido[1,2-a]...)
Affinity DataKi:  3.80nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

LigandPNGBDBM694185(8,9-dichloro-7-(2-fluorophenyl)-5H-pyrimido[1,2-a]...)
Affinity DataKi:  57.9nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

LigandPNGBDBM694185(8,9-dichloro-7-(2-fluorophenyl)-5H-pyrimido[1,2-a]...)
Affinity DataKi:  63.4nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

LigandPNGBDBM694185(8,9-dichloro-7-(2-fluorophenyl)-5H-pyrimido[1,2-a]...)
Affinity DataKi:  716nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent