BDBM694195 (5S)-8-chloro-7-(2,6-difluorophenyl)-2-ethyl-5-methyl-9-(trifluoromethyl)-5H-pyrimido[1,2-a][1,4]benzodiazepin-3-one::US20240287082, Example 11

SMILES CCc1cn-2c(nc1=O)[C@H](C)N=C(c1c(F)cccc1F)c1c(Cl)c(ccc-21)C(F)(F)F

InChI Key InChIKey=BJKBUWXMDQNLGD-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 694195   

LigandPNGBDBM694195((5S)-8-chloro-7-(2,6-difluorophenyl)-2-ethyl-5-met...)
Affinity DataKi:  4.10nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

LigandPNGBDBM694195((5S)-8-chloro-7-(2,6-difluorophenyl)-2-ethyl-5-met...)
Affinity DataKi:  40.1nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

LigandPNGBDBM694195((5S)-8-chloro-7-(2,6-difluorophenyl)-2-ethyl-5-met...)
Affinity DataKi:  167nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

LigandPNGBDBM694195((5S)-8-chloro-7-(2,6-difluorophenyl)-2-ethyl-5-met...)
Affinity DataKi:  6.09E+3nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent