BDBM694468 US20240293412, Compound TABLE2.21

SMILES CSc1ccc(CNC(=O)[C@H]2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(C)cc2)cc1

InChI Key InChIKey=VWUOWUZLQDJSCV-UHFFFAOYSA-N

Data  1 Kd  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 694468   

TargetNicotinamide phosphoribosyltransferase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM694468(US20240293412, Compound TABLE2.21)
Affinity DataEC50:  1nMAssay Description:Activation of C-terminal 6His-tagged human wild type NAMPT using NAM and PRPP as substrate measured for 30 mins in presence of ATP by fluorescence ba...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM694468(US20240293412, Compound TABLE2.21)
Affinity DataEC50:  1.00E+3nMAssay Description:All FP measurements were performed at room temperature in PBS buffer containing 0.01% Triton-X 100 and 1% DMSO in black 384-well plates. Measurements...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM694468(US20240293412, Compound TABLE2.21)
Affinity DataEC50:  1.00E+3nMAssay Description:Positive allosteric modulation of C-terminal His6-tagged wild type human NAMPT using NAM and PRPP as substrates measured for 1 hr by NMNAT1-coupled e...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM694468(US20240293412, Compound TABLE2.21)
Affinity DataKd:  1.46E+3nMAssay Description:Displacement of FP-probe ZN-2-102 from C-terminal His6-tagged wild type human NAMPT rear channel assessed as dissociation constant by fluorescence po...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed