BDBM694691 9-(2,6-difluorophenyl)-3-methyl-16-oxa-18-thia-2,4,5,8-tetrazatetracyclo[8.8.0.02,6.011,17]octadeca-1(10),3,5,8,11::US20240294543, Example 18

SMILES Cc1nnc2CN=C(c3c4CCCCOc4sc3-n12)c1c(F)cccc1F

InChI Key InChIKey=KQQPWYMLATZBCF-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 694691   

LigandPNGBDBM694691(9-(2,6-difluorophenyl)-3-methyl-16-oxa-18-thia-2,4...)
Affinity DataKi:  1.84nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent

LigandPNGBDBM694691(9-(2,6-difluorophenyl)-3-methyl-16-oxa-18-thia-2,4...)
Affinity DataKi:  20.9nMAssay Description:Table 2: Electrophysiological experiments were performed using the Roboocyte instrument (MultiChannelSystems, Reutlingen, Germany) on days 3 to 5 aft...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent

LigandPNGBDBM694691(9-(2,6-difluorophenyl)-3-methyl-16-oxa-18-thia-2,4...)
Affinity DataKi:  20.9nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent

LigandPNGBDBM694691(9-(2,6-difluorophenyl)-3-methyl-16-oxa-18-thia-2,4...)
Affinity DataKi:  55.1nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent

LigandPNGBDBM694691(9-(2,6-difluorophenyl)-3-methyl-16-oxa-18-thia-2,4...)
Affinity DataKi:  428nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent