BDBM694699 (8S)-10-(2,6-difluorophenyl)-4,8-dimethyl-19-thia-2,6,9-triazatetracyclo[9.8.0.02,7.012,18]nonadeca-1(11),3,6,9,12::US20240294543, Example 26

SMILES C[C@@H]1N=C(c2c3CCCCCc3sc2-n2cc(C)c(=O)nc12)c1c(F)cccc1F

InChI Key InChIKey=LFXPMMGEDYWIHD-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 694699   

LigandPNGBDBM694699((8S)-10-(2,6-difluorophenyl)-4,8-dimethyl-19-thia-...)
Affinity DataKi:  3.78nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent

LigandPNGBDBM694699((8S)-10-(2,6-difluorophenyl)-4,8-dimethyl-19-thia-...)
Affinity DataKi:  32nMAssay Description:Table 2: Electrophysiological experiments were performed using the Roboocyte instrument (MultiChannelSystems, Reutlingen, Germany) on days 3 to 5 aft...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent

LigandPNGBDBM694699((8S)-10-(2,6-difluorophenyl)-4,8-dimethyl-19-thia-...)
Affinity DataKi:  32nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent

LigandPNGBDBM694699((8S)-10-(2,6-difluorophenyl)-4,8-dimethyl-19-thia-...)
Affinity DataKi:  6.04E+3nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent