BDBM694704 US20240294543, Example 31::US20240294543, Example 32::[(7S)-9-(2,6-Difluorophenyl)-7-methyl-13,16-dioxa-18-thia-2,3,5,8-tetrazatetracyclo[8.8.0.02,6.011,17]octadeca-1(10),3,5,8,11

SMILES CCOC1CN(C1)C(=O)c1nc2[C@H](C)N=C(c3c4COCCOc4sc3-n2n1)c1c(F)cccc1F

InChI Key InChIKey=LGVUKUTZGCPEKH-UHFFFAOYSA-N

Data  9 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 694704   

LigandPNGBDBM694704([(7S)-9-(2,6-Difluorophenyl)-7-methyl-13,16-dioxa-...)
Affinity DataKi:  1.88nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent

LigandPNGBDBM694704([(7S)-9-(2,6-Difluorophenyl)-7-methyl-13,16-dioxa-...)
Affinity DataKi:  2.40nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent

LigandPNGBDBM694704([(7S)-9-(2,6-Difluorophenyl)-7-methyl-13,16-dioxa-...)
Affinity DataKi:  5.5nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent

LigandPNGBDBM694704([(7S)-9-(2,6-Difluorophenyl)-7-methyl-13,16-dioxa-...)
Affinity DataKi:  5.60nMAssay Description:Table 2: Electrophysiological experiments were performed using the Roboocyte instrument (MultiChannelSystems, Reutlingen, Germany) on days 3 to 5 aft...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent

LigandPNGBDBM694704([(7S)-9-(2,6-Difluorophenyl)-7-methyl-13,16-dioxa-...)
Affinity DataKi:  7.70nMAssay Description:Table 2: Electrophysiological experiments were performed using the Roboocyte instrument (MultiChannelSystems, Reutlingen, Germany) on days 3 to 5 aft...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent

LigandPNGBDBM694704([(7S)-9-(2,6-Difluorophenyl)-7-methyl-13,16-dioxa-...)
Affinity DataKi:  7.70nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent

LigandPNGBDBM694704([(7S)-9-(2,6-Difluorophenyl)-7-methyl-13,16-dioxa-...)
Affinity DataKi:  43.6nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent

LigandPNGBDBM694704([(7S)-9-(2,6-Difluorophenyl)-7-methyl-13,16-dioxa-...)
Affinity DataKi:  4.54E+3nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent

LigandPNGBDBM694704([(7S)-9-(2,6-Difluorophenyl)-7-methyl-13,16-dioxa-...)
Affinity DataKi:  5.78E+3nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent