BDBM694839 US20240294551, Example 5

SMILES CN1C[C@H](F)C[C@H]1COc1nc2N3CCC[C@](C)(C3)NC(=O)CCCc3c(F)ccc4cc(O)cc(-c5ncc2c(n1)c5F)c34

InChI Key InChIKey=OSJJQBKMKGRWIT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 694839   

TargetGTPase KRas [G12D](Human)
Amgen

US Patent
LigandPNGBDBM694839(US20240294551, Example 5)
Affinity DataIC50: 1nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Amgen

US Patent
LigandPNGBDBM694839(US20240294551, Example 5)
Affinity DataIC50: 1nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent