BDBM694916 US20240294551, Example 82

SMILES O=C1CCCCc2c(Cl)cc3[nH]ncc3c2-c2ncc3c(nc(OC[C@@]45CCCN4C[C@H](F)C5)nc3c2F)N2CCCC[C@H](C2)O1

InChI Key InChIKey=ORFWTAZFLVFEMH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 694916   

TargetGTPase KRas [G12D](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 694916BDBM694916(US20240294551, Example 82)
Affinity DataIC50: 1nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 694916BDBM694916(US20240294551, Example 82)
Affinity DataIC50: 2nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent