BDBM695101 US20240294551, Example 267

SMILES CN1CCC[C@H]1COc1nc2N3CC[C@H]4CCN([C@H]4C3)C(=O)COCCCc3c(Cl)cc4[nH]ncc4c3-c3ncc2c(n1)c3F

InChI Key InChIKey=ULPCWNDVKQUOGG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 695101   

TargetGTPase KRas [G12D](Human)
Amgen

US Patent
LigandPNGBDBM695101(US20240294551, Example 267)
Affinity DataIC50: 2nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Amgen

US Patent
LigandPNGBDBM695101(US20240294551, Example 267)
Affinity DataIC50: 4nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent