BDBM695730 US12084420, Compound 333b

SMILES CCS(=O)(=O)Nc1ccc2N(C[C@@]3(CC[C@@H](CC3)C(F)F)c2c1)C(=O)c1cccc(c1)S(=O)(=O)NC(C)(C)C

InChI Key InChIKey=UNTQOYJJYGPBCQ-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 695730   

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695730(US12084420, Compound 333b)
Affinity DataKi:  0.770nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695730(US12084420, Compound 333b)
Affinity DataIC50: 33nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent