BDBM695861 (S)-5-cyclopropyl-5-(3-(7,8-dichloro-1-methyl-1,2,4,5-tetrahydro-3H-benzo [d]azepin-3-yl)-3-oxopropyl)imidazolidine-2,4-dione 37::US20240299360, Example 37

SMILES CC1CN(CCc2cc(Cl)c(Cl)cc12)C(=O)CC[C@]1(NC(=O)NC1=O)C1CC1

InChI Key InChIKey=LBFZDWQGADLLKS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 695861   

TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM695861(US20240299360, Example 37 | (S)-5-cyclopropyl-5-(3...)
Affinity DataIC50: 5nMAssay Description:Table 1: A FRET (fluorescence resonance energy transfer) peptide was cleaved by recombinant ADAMTS-4 or ADAMTS-5 proteins into two separate fragments...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/8/2025
Entry Details
US Patent

TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM695861(US20240299360, Example 37 | (S)-5-cyclopropyl-5-(3...)
Affinity DataIC50: 13nMAssay Description:Table 2: In this assay, the enzymatic activity of recombinant ADAMTS-5 protein (catalog #2198-AD, R&D Systems) was assayed with a protein substrate, ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/8/2025
Entry Details
US Patent

TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM695861(US20240299360, Example 37 | (S)-5-cyclopropyl-5-(3...)
Affinity DataIC50: 16nMAssay Description:Table 2: In this assay, the enzymatic activity of recombinant ADAMTS-5 protein (catalog #2198-AD, R&D Systems) was assayed with a protein substrate, ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/8/2025
Entry Details
US Patent