BDBM696651 (R) or (S) N-(5-(3-hydroxy-3- (2-hydroxypropan-2- yl)pyrrolidin-1-yl)-2- (trifluoromethyl)pyridin-3-yl)- 6-(1-(2,2,2-trifluoroethyl)-1H- pyrazol-4-yl)picolinamide::US20240308980, Ex-1.16::US20240308980, Ex-1.17

SMILES CC(C)(O)C1(O)CCN(C1)c1cnc(c(NC(=O)c2cccc(n2)-c2cnn(CC(F)(F)F)c2)c1)C(F)(F)F

InChI Key InChIKey=UOOSBFSVYIDLIZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 696651   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM696651(US20240308980, Ex-1.16 | US20240308980, Ex-1.17 | ...)
Affinity DataIC50: 870nMAssay Description:Compound potency against LRRK2 kinase activity was determined using LanthaScreen technology from Life Technologies Corporation (Carlsbad, CA) using a...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/16/2025
Entry Details
US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM696651(US20240308980, Ex-1.16 | US20240308980, Ex-1.17 | ...)
Affinity DataIC50: 5.10E+3nMAssay Description:Compound potency against LRRK2 kinase activity was determined using LanthaScreen technology from Life Technologies Corporation (Carlsbad, CA) using a...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/16/2025
Entry Details
US Patent