BDBM696745 (R) or (S) N-(2-(3-hydroxy-3- methylpyrrolidin-1-yl)-5- (trifluoromethyl)pyridin-4-yl)-6- (1-methyl-1H-pyrazol-4- yl)picolinamide::US20240308980, Ex-4.16::US20240308980, Ex-4.17

SMILES Cn1cc(cn1)-c1cccc(n1)C(=O)Nc1cc(ncc1C(F)(F)F)N1CCC(C)(O)C1

InChI Key InChIKey=VBXSAFDQBCKETG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 696745   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM696745(US20240308980, Ex-4.16 | (R) or (S) N-(2-(3-hydrox...)
Affinity DataIC50: 2.34E+3nMAssay Description:Compound potency against LRRK2 kinase activity was determined using LanthaScreen technology from Life Technologies Corporation (Carlsbad, CA) using a...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/16/2025
Entry Details
US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM696745(US20240308980, Ex-4.16 | (R) or (S) N-(2-(3-hydrox...)
Affinity DataIC50: 4.11E+3nMAssay Description:Compound potency against LRRK2 kinase activity was determined using LanthaScreen technology from Life Technologies Corporation (Carlsbad, CA) using a...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/16/2025
Entry Details
US Patent