BDBM696792 6-(1-((1- cyanocyclopropyl)methyl)-1H- pyrazol-4-yl)-N-(6-((3S,4s,5R)- 4-hydroxy-3,4,5- trimethylpiperidin-1-yl)-2- methylpyrimidin-4- yl)picolinamide::US20240308980, Ex-7.4

SMILES C[C@H]1CC(C[C@@H](C)[C@@]1(C)O)c1cc(NC(=O)c2cccc(n2)-c2cnn(CC3(CC3)C#N)c2)nc(C)n1

InChI Key InChIKey=RDNNZGJAPDBXRB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 696792   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM696792(6-(1-((1- cyanocyclopropyl)methyl)-1H- pyrazol-4-y...)
Affinity DataIC50: 670nMAssay Description:Compound potency against LRRK2 kinase activity was determined using LanthaScreen technology from Life Technologies Corporation (Carlsbad, CA) using a...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/16/2025
Entry Details
US Patent