BDBM697213 1-[[2- (difluoromethoxy) pyridin-4- yl]methyl]-3- [(2R,3S)-3- hydroxyspiro[3.3] heptan-2-yl]urea::US20240316020, Example 28

SMILES O[C@@H]1[C@@H](CC11CCC1)NC(=O)NCc1ccnc(OC(F)F)c1

InChI Key InChIKey=PKKATWMGZDLLPZ-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 697213   

LigandPNGBDBM697213(US20240316020, Example 28 | 1-[[2- (difluoromethox...)
Affinity DataEC50:  500nMAssay Description:Human Kv7.2, Kv7.4 or Kv7.5/7.3 channels were evaluated using a voltage protocol in which cells were voltage-clamped at a holding potential of -60 mV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent

LigandPNGBDBM697213(US20240316020, Example 28 | 1-[[2- (difluoromethox...)
Affinity DataEC50:  500nMAssay Description:Human Kv7.2, Kv7.4 or Kv7.5/7.3 channels were evaluated using a voltage protocol in which cells were voltage-clamped at a holding potential of -60 mV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent

LigandPNGBDBM697213(US20240316020, Example 28 | 1-[[2- (difluoromethox...)
Affinity DataEC50: >3.00E+4nMAssay Description:Human Kv7.2, Kv7.4 or Kv7.5/7.3 channels were evaluated using a voltage protocol in which cells were voltage-clamped at a holding potential of -60 mV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent