BDBM698825 9-isopropyl-N-(5-(piperazin-1-yl)pyridin-2-yl)isoxazolo[5,4-H]quinazolin-2-amine hydrochloride (I-1)::US12600731, Example I-1

SMILES CC(C)c4noc5ccc3cnc(Nc2ccc(N1CCNCC1)cn2)nc3c45

InChI Key InChIKey=PDOYHMFVGNBZNK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 698825   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Chengdu Cynogen Bio-Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 698825BDBM698825(9-isopropyl-N-(5-(piperazin-1-yl)pyridin-2-yl)isox...)
Affinity DataIC50: 2nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2026
Entry Details
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Chengdu Cynogen Bio-Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 698825BDBM698825(9-isopropyl-N-(5-(piperazin-1-yl)pyridin-2-yl)isox...)
Affinity DataIC50: 7nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2026
Entry Details
US Patent