BDBM698836 N-(5-((4-ethylpiperazin-1-yl) methyl)pyridin-2-yl)-9- isopropylisoxazolo[5,4-H] quinazolin-2-amine::US12600731, Example I-12

SMILES CCN1CCN(Cc2ccc(Nc3ncc4ccc5onc(C(C)C)c5c4n3)nc2)CC1

InChI Key InChIKey=XINQUBFMUACJAB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 698836   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Chengdu Cynogen Bio-Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 698836BDBM698836(N-(5-((4-ethylpiperazin-1-yl) methyl)pyridin-2-yl)...)
Affinity DataIC50: 9nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2026
Entry Details
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Chengdu Cynogen Bio-Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 698836BDBM698836(N-(5-((4-ethylpiperazin-1-yl) methyl)pyridin-2-yl)...)
Affinity DataIC50: 40nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2026
Entry Details
US Patent