BDBM698841 4-(6-((9-isopropylisoxazolo[5,4- H]quinazolin-2-yl)amino) pyridin-3-yl)thiomorpholine 1,1-dioxide::US12600731, Example I-17

SMILES CC(C)c1noc2ccc3cnc(Nc4ccc(N5CCS(=O)(=O)CC5)cn4)nc3c12

InChI Key InChIKey=GWJXLMBSCDYORX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 698841   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Chengdu Cynogen Bio-Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 698841BDBM698841(4-(6-((9-isopropylisoxazolo[5,4- H]quinazolin-2-yl...)
Affinity DataIC50: 5nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2026
Entry Details
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Chengdu Cynogen Bio-Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 698841BDBM698841(4-(6-((9-isopropylisoxazolo[5,4- H]quinazolin-2-yl...)
Affinity DataIC50: 21nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2026
Entry Details
US Patent