BDBM698843 9-isobutyl-N-(5-(4-methylpiperazin-1- yl)pyridin-2-yl)isoxazolo[5,4-H] quinazolin-2-amine::US12600731, Example I-19

SMILES CC(C)Cc1noc2ccc3cnc(Nc4ccc(N5CCN(C)CC5)cn4)nc3c12

InChI Key InChIKey=DJLQEDBTPZTZDA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 698843   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Chengdu Cynogen Bio-Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 698843BDBM698843(9-isobutyl-N-(5-(4-methylpiperazin-1- yl)pyridin-2...)
Affinity DataIC50: 7nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2026
Entry Details
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Chengdu Cynogen Bio-Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 698843BDBM698843(9-isobutyl-N-(5-(4-methylpiperazin-1- yl)pyridin-2...)
Affinity DataIC50: 37nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2026
Entry Details
US Patent