BDBM698868 2-(1-(2-((1- ((dimethylamino)methyl)cyclopropyl) methoxy)-6-(3-hydroxy-8-iodo-1- naphthoyl)-6,7-dihydro-5H-pyrrolo [3,4-d]pyrimidin-4-yl)-3- hydroxypiperidin-3- yl)acetonitrile::US20240317759, Example 78

SMILES CC(C)c1noc2ccc3cnc(Nc4ccc(C(=O)N5CCNCC5)cc4)nc3c12

InChI Key InChIKey=WEVIFVJHTGULSZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 698868   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Chengdu Cynogen Bio-Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 698868BDBM698868((4-((9-isopropylisoxazolo[5,4-H] quinazolin-2-yl)a...)
Affinity DataIC50: 3nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2026
Entry Details
US Patent

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Chengdu Cynogen Bio-Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 698868BDBM698868((4-((9-isopropylisoxazolo[5,4-H] quinazolin-2-yl)a...)
Affinity DataIC50: 5nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2026
Entry Details
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Chengdu Cynogen Bio-Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 698868BDBM698868((4-((9-isopropylisoxazolo[5,4-H] quinazolin-2-yl)a...)
Affinity DataIC50: 9nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2026
Entry Details
US Patent